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Biomet Cementing University

Dr Thorsten Gehrke, MD

Thorsten Gehrke, MD,
Endo-Klinik Hamburg,
Specialist Clinic for Bone and Joint Surgery.
Hamburg, Germany

Both the Swedish and Norwegian Arthroplasty Registers have shown that antibiotic-loaded cements are an effective prophylactic concept against septic complications in arthroplasty. Biomet’s antibiotic-loaded cements contain gentamicin, which is effective against most bacteria involved in post operative infections and is the antibiotic that shows the best release from bone cements.

Biomet Europe´s revision bone cement contains both gentamicin and clindamycin, a combination that has shown excellent results in clinical studies conducted at the Endo-Klinik in Hamburg.High local antibiotic releaseThe advantage of antibiotic-loaded cements is their local release of high antibiotic concentrations at the site of implantation. The local release of antibiotics causes low rise in serum or urine concentrations and therefore does not produce the side effects associated with systemic antibiotics. The high initial and subsequent protracted antibiotic release of the bone cement provides effective protection of the implant.Cost savingsIn many countries antibiotic-loaded bone cements are used in primary operations because of the reduced risk of revision and consequent long-term savings. A double-loaded antibiotic bone cement provides extra security in cases such as one- and two-stage revisions, revisions for infections and risk patients with severely decreased immunity.

One- and two-stage revision

Revision procedures are performed in one or two sessions. In a two-stage revision, a temporary antibiotic cement joint spacer may be used for local antibiotic protection.

Clinical results
The Norwegian Arthroplasty Register has demonstrated that using a combination of an antibiotic-loaded cement and systemic antibiotics reduces the incidence of revisions more than any other regime.

Double-loaded for double protection
Gentamicin and clindamycin is a combination known to have a bactericidal effect on more than 90% of the bacteria common to infected arthroplasty cases.